Targeting Longevity 2026 will explore the recent advances in ageing and longevity medicine within the humans.
Our Strategy: From Targets to Systems
Longevity is often approached as a problem to solve – a pathway to correct, a marker to optimize, a target to hit.
But aging does not behave like a defect.
Aging is a dynamic, systemic process, shaped by continuous interactions between biological systems that regulate energy, metabolism, immunity, inflammation, and stress adaptation over time.
The strategy of Targeting Longevity is built on a simple but demanding idea:
to understand aging before attempting to correct it.
Why a systems approach to longevity ?
Biological systems do not age in isolation.
Mitochondria, microbiota, metabolic regulation, immune balance, and redox signaling form an interconnected network that adapts continuously across the lifespan.
Focusing on a single pathway may produce measurable effects, but it rarely restores coordination — and coordination is central to healthy aging.
Our strategy therefore shifts the question from:
“Which target should we fix?” to: “How do biological systems interact, adapt, and sometimes lose balance with age?”
Mitochondria and microbiota at the center
At the heart of this strategy lies the dialogue between mitochondria and microbiota.
Mitochondria regulate cellular energy, stress responses, and adaptive capacity.
The gut microbiota influences metabolism, immune tone, inflammation, and systemic signaling.
These two systems communicate continuously and respond to environmental, nutritional, and physiological cues. Their interaction helps shape aging trajectories, rather than isolated outcomes.
Understanding this dialogue is essential to move beyond linear and static models of longevity.
From intervention to trajectory
Longevity cannot be managed through late, one-time corrections alone.
Aging trajectories are shaped early, evolve dynamically, and differ between individuals and species.
Our strategy emphasizes:
- Dynamics rather than static endpoints
- Resilience rather than optimization
- Coordination rather than isolated correction
This approach applies to humans as well as to companion animals, including horses, dogs, and cats, where aging also reflects system-level adaptations over time.
Why longevity needs a task force
If aging is a systems phenomenon, no single discipline can address it alone.
Progress requires coordinated expertise across mitochondria biology, microbiota research, metabolism, immunology, systems medicine, and clinical practice.
That is why Targeting Longevity is conceived as a collective scientific task force, bringing together complementary perspectives to reconnect fragmented knowledge into a coherent strategy.
A strategic goal
Our goal is not to promote a single solution, molecule, or technology.
It is to reshape how longevity is understood and approached, by aligning research and medicine with biological reality.
Because the future of longevity may not lie in doing more of the same but in learning to see aging as a living system.